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Antagonism of the trypanocide, berenil, and the nematocide, morantel, by tubocurarine

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Summary

The tubocurarine antagonism, (pA2 values) of acetylcholine, suxamethonium, morantel and berenil were calculated as 6.5, 6.3, 6.4 and 6.2 respectively with the toad rectus abdominis muscle. It is suggested that tubocurarine competitively inhibits the morantel and berenil induced contracture of the toad rectus abdominis muscle.

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Bamgbose, S.O.A. Antagonism of the trypanocide, berenil, and the nematocide, morantel, by tubocurarine. Naunyn-Schmiedeberg's Arch. Pharmacol. 280, 103–106 (1973). https://doi.org/10.1007/BF00505359

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  • DOI: https://doi.org/10.1007/BF00505359

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