Mechanisms involved in the trans-synaptic increase of tyrosine hydroxylase and dopamine-β-hydroxylase activity in sympathetic ganglia

  • I. Hanbauer
  • I. J. Kopin
  • E. Costa


Exposure at 4°C for 4 h increases the activity of tyrosine hydroxylase (TH) and dopamine-β-hydroxylase in superior cervical ganglia of bilateral adrenal demedullated (three weeks before) rats, but not that of normal rats. One or two weeks after adrenal demedullation, TH and DBH activities failed to be increased after exposure to 4°C for 4 h. Pretreatment with a nicotinic receptor antagonist (mecamylamine 15 μmoles/kg i.p.) abolishes the induction of TH but several injections of this drug beginning either after termination of cold exposure or 24 h later fail to inhibit TH induction. Decentralization performed at the end of cold exposure, 17 or 24 h later abolishes TH and DBH induction elicited by cold.

Key words

Superior Cervical Ganglion Cold Exposure Tyrosine Hydroxylase Decentralization Mecamylamine 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • I. Hanbauer
    • 1
  • I. J. Kopin
    • 1
  • E. Costa
    • 2
  1. 1.Laboratory of Clinical ScienceNational Institute of Mental HealthBethesda
  2. 2.Laboratory of Preclinical PharmacologyNational Institute of Mental Health Saint Elizabeths HospitalWashington, D.C.U.S.A.

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