Summary
Diazoxide significantly decreased the blood pressure and relaxed the uterine muscle in anaesthetized normotensive rats. A marked elevation of blood glucose followed the intravenous injection of diazoxide. The hyperglycemic and the uterine relaxing response could be significantly decreased by injection of propranolol prior to diazoxide. The hypotensive effect was not diminished by propranolol, however. In liver and uterus the content of cAMP was increased following diazoxide treatment in vivo. The rise in cAMP could be completely inhibited by propranolol, indicating a β-receptor stimulation being the cause of the cAMP elevation.
This is a preview of subscription content, log in via an institution to check access.
References
Andersson RGG (1973) Cyclic AMP as a mediator of the relaxing action of papaverine, nitroglycerin, diazoxide and hydralazine in intestinal and vascular smooth muscle. Acta pharmacol Toxicol 32:321–336
Fajans SS, Floyd JC, Knopf RF, Rull J, Guntsche E, Conn JW (1966) Benzothiadiazine suppression of insulin release from normal and abnormal islet tissue in man. J Clin Invest 45: 481–488
Finnerty FA (1970) Treatment of acute hypertension in pregnancy. Obstet Gynecol Digest 12:30–37
Finnerty FA, Kakaviatos N, Tuckman J, Magill J (1963) Clinical evaluation of diazoxide. A new treatment for acute hypertension. Circulation 28:203–208
Gilman AG (1970) A protein binding assay for adenosine 3′-5′ cyclic monophosphate. Proc Nat Acad Sci USA 67:305–313
Henrich WL, Cronin R, Miller PD, Anderson RJ Hypotensive sequelae of diazoxide and hydralazine therapy. JAMA 237: 264–265
Johansson S, Andersson RGG, Wikberg J (1977) Mechanical and metabolic effects of diazoxide in rat uterus. Acta Pharmacol Toxicol 41:328–336
Landesman R, Coatinho EM, Wilson KH, Lopes ACU (1968) The relaxing effect of diazoxide on nongravid human myometrium in vivo. Am J Obstet Gynecol 102:1080–1084
Landesman R, Desousa FJA, Coutinho EM, Wilson KH, Desousa EMB (1969) The inhibitory effect of diazoxide in normal term labour. Am J Obstet Gynecol 103:430–433
Loubatieres A, Mariani MM, Alric A (1968) The action of diazoxide on insulin secretion, medulla adrenal secretion and the liberation of catecholamines. Ann NY Acad Sci 150:226–232
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
Rubin AA, Roth FE, Taylor RM, Rosenkilde H (1962) Pharmacology of diazoxide, an antihypertensive nondiuretic benzothiadiazine. J Pharmacol Exp Ther 136:344–352
Schneider-Affeld F, Kubli F (1978) Kurzzeittokolyse von Prostaglandinwehen — Fenoterol und Diazoxid in Vergleich. Arch Gynäkol 225:67–74
Senft G (1968) Biochemical aspects of the hyperglycemic action of diazoxide. Ann NY Acad Sci 150:242–255
Staquet M, Yabo J, Viktoria J, Wolff FW (1965) An adrenergic mechanism for hyperglycemia induced by diazoxide. Metabolism 14:1000–1009
Tabachnich IIA, Gulbenkian A, Seidman FS (1964) The effect of a benzothiadiazine, diazoxide on carbohydrate metabolism. Diabetes 13:408–418
Tabachnich IIA, Guilbenkian A (1968) Mechanism of diazoxide hyperglycemia in animals. Ann NY Acad Sci 150:204–218
Wohl AJ, Hausler LH, Roth FE (1967) Studies on the mechanism of antihypertensive action of diazoxide. In vitro vascular pharmacodynamics. J Pharmacol Exp. Ther 158:531–539
Wohl AJ, Hausler LM, Roth FE (1968) The role of calcium in the mechanism of the antihypertensive action of diazoxide. Life Sci 7:381–387
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johansson, S.R.M., Andersson, R.G.G. Decrease of some metabolic and physiologic effects of diazoxide by propranolol in rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 316, 190–193 (1981). https://doi.org/10.1007/BF00505316
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00505316