Summary
The antimuscarinic activity of mianserin and amitriptyline was investigated in the cat superior cervical ganglion using McN-A-343 as a muscarinic agonist. Mianserin was found to have a similar order of potency to amitriptyline in this preparation, in contrast to the marked difference in their antimuscarinic activities on non-neuronal muscarinic receptors.
These findings suggest that the action of mianserin on neuronal muscarinic receptors is more important than that predicted from studies on non-neuronal receptors and may be related to its anti-depressant activity.
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Kwok, Y.H., Mitchelson, F. Comparison of the antimuscarinic activity of mianserin and amitriptyline in the cat superior cervical ganglion. Naunyn-Schmiedeberg's Arch. Pharmacol. 316, 161–164 (1981). https://doi.org/10.1007/BF00505311
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DOI: https://doi.org/10.1007/BF00505311