Summary
We compared the effects of phencyclidine (PCP) and methamphetamine on body temperature and brain histamine turnover in mice. Methamphetamine at 5 and 10 mg/kg produced dose-related increases in rectal temperature, whereas PCP given in the same doses had no significant effect. In mice pretreated with α-fluoromethylhistidine, an inhibitor of histidine decarboxylase, PCP produced a marked hyperthermia. PCP markedly accelerated brain histamine turnover, as measured by the accumulation of telemethylhistamine, a predominant metabolite of brain histamine, following administration of pargyline. Methamphetamine had no significant effect on the histamine dynamics. These results suggest involvement of brain histaminergic neurons in the action of PCP but not methamphetamine, and the presence of a histaminergic thermoregulatory mechanism.
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References
Clark WG, Cumby HR (1976) Biphasic changes in body temperature produced by intracerebroventricular injections of histamine in the cat. J Physiol 261:235–253
Cox B, Green MD, Lomax P (1976) Thermoregulatory effects of histamine. Experientia 32:498–500
Garbarg M, Barbin G, Rodergas E, Schwartz JC (1980) Inhibition of histamine synthesis in brain by α-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies. J Neurochem 35:1045–1052
Glick SD, Guido RA (1982) Naloxone antagonism of the thermoregulatory effects of phencyclidine. Science 217:1272–1273
Green JP, Johnson CL, Weinstein H (1978) Histamine as a neurotransmitter. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: a generation progress Raven Press, New York, pp 319–332
Hough LB, Domino EF (1979) Tele-methylhistamine oxidation by type B monoamine oxidase. J Pharmacol Exp Ther 208:422–428
Hough LB, Khandelwal JK, Green JP (1982) Effects of pargyline on tele-methylhistamine and histamine in rat brain. Biochem Pharmacol 31:4074–4076
Itoh Y, Nishibori M, Oishi R, Saeki K (1984) Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice. Neurosci Lett 48:305–309
Itoh Y, Oishi R, Nishibori M, Saeki K (1985) Phencyclidine and the dynamics of mouse brain histamine. J Pharmacol Exp Ther 235: (in press)
Johnson KM (1983) Phencyclidine: behavioral and biochemical evidence supporting a role for dopamine. Fed Proc 42:2579–2583
Kollonitsch J, Patchett AA, Marburg S, Maycock AL, Perkins LM, Doldouras GA, Duggan DE, Aster SD (1978) Selective inhibitors of biosynthesis of aminergic neurotransmitters. Nature 274:906–908
Lin MT, Chandra A, Chern YF, Tsay BL (1980) Effects of intracerebroventricular injection of d-amphetamine on metabolic, respiratory, and vasomotor activities and body temperatures in the rat. Can J Physiol Pharmacol 58:903–908
Lomax P, Green MD (1981) Histaminergic neurons in the hypothalamic thermoregulatory pathways. Fed Proc 40:2741–2745
Matsumoto C, Griffin W (1971) Antagonism of (+)-amphetamine-induced hyperthermia in rats by pimozide. J Pharm Pharmacol 23:710
Morpurgo C, Theobald W (1967) Pharmacological modifications of the amphetamine-induced hyperthermia in rats. Eur J Pharmacol 2:287–294
Nabeshima T, Sivam SP, Ho IK (1983) Effect of morphine on the responses to and disposition of phencyclidine in mice. I. Enhancement of phencyclidine effects by acute morphine administration. J Pharmacol Exp Ther 225:325–331
Oishi R, Nishibori M, Saeki K (1984) Regional differences in the turnover of neuronal histamine in the rat brain. Life Sciences 34:691–699
Oishi R, Itoh Y, Nishibori M, Saeki K (1985) Δ9-Tetrahydrocannabinol decreases turnover of brain histamine. J Pharmacol Exp Ther 232:513–518
Reid WD (1970) Turnover rate of brain 5-hydroxytryptamine increased by d-amphetamine. Br J Pharmacol 40:483–491
Schayer RW, Reilly MA (1973) Metabolism of 14C-histamine in brain. J Pharmacol Exp Ther 187:34–39
Schwartz JC, Pollard H, Quach TT (1980) Histamine as a neurotransmitter in mammalian brain: neurochemical evidence. J Neurochem 35:26–33
Slotkin TA, Bartolome J, Whitmore WL (1983) Developmental effects of α-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines. Life Sciences 33:2137–2145
Smith RC, Meltzer HY, Arora RC, Davis JM (1977) Effects of phencyclidine on [3H] catecholamine and [3H] serotonin uptake in synaptosomal preparations from rat brain. Biochem Pharmacol 26:1435–1439
Sturgeon RD, Fessber RG, Meltzer HY (1979) Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. Eur J Pharmacol 59:169–179
Taube HD, Montel H, Hau G, Starke K (1975) Phencyclidine and ketamine: comparison with the effect of cocaine on the noradrenergic neurons of the rat brain cortex. Naunyn-Schmiedeberg's Arch Pharmacol 291:47–54
Tsuruta Y, Kohashi K, Ohkura Y (1981) Simultaneous determination of histamine and Nτ-methylhistamine in human urine and rat brain by high-performance liquid chromatography with fluorescence detection. J Chromatogr 224:105–110
Vickroy TW, Johnson KM (1982) Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices. J Pharmacol Exp Ther 223:669–674
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Itoh, Y., Oishi, R., Nishibori, M. et al. Comparison of effects of phencyclidine and methamphetamine on body temperature in mice: a possible role for histamine neurons in thermoregulation. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, 293–296 (1986). https://doi.org/10.1007/BF00504870
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DOI: https://doi.org/10.1007/BF00504870