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The metabolizing systems involved in the inactivation of catecholamines

  • Rudolf Buchheim Lecture
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References

  • Azevedo I, Bönisch H, Osswald W, Trendelenburg U (1983) Autoradiographic study of rat hearts perfused with 3H-isoprenaline. Naunyn-Schmiedeberg's Arch Pharmacol 322:1–5

    Google Scholar 

  • Barone S, Stitzel RE, Head RJ (1983) The vascular extraneuronal uptake (ENU) and O-methylation of isoproterenol (ISO) is a stereoselective process. Pharmacologist 25:267

    Google Scholar 

  • Barone S, Stitzel RE, Head RJ (1985) The stereoselective O-methylation of isoprenaline in the isolated rabbit thoracic aorta. Naunyn-Schmiedeberg's Arch Pharmacol 329:9–17

    Google Scholar 

  • Blaschko H, Muscholl E (1972) Catecholamines, Handbook of experimental pharmacology, vol 33. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Bönisch H (1986) The role of co-transported sodium in the effect of indirectly acting amines. Naunyn-Schmiedeberg's Arch Pharmacol 332:135–141

    Google Scholar 

  • Bönisch H, Friedrich U, Fritsch H, Harder R (1984) Transport of noradrenaline across the cell membrane of isolated neuronal cells with special reference to PC-12 cells. In: Fleming WW, Graefe KH, Langer SZ, Weiner N (eds) Neuronal and extraneuronal events in autonomic pharmacology Raven Press. New York, NY, pp 63–74

    Google Scholar 

  • Bönisch H, Bryan LJ, Henseling M, O'Donnell SR, Stockmann P, Trendelenburg U (1985) The effect of various ions on uptake2 of catecholamines. Naunyn-Schmiedeberg's Arch Pharmacol 328:407–416

    Google Scholar 

  • Bryan LJ, O'Donnell SR (1984) Stereoselectivity of extraneuronal uptake of catecholamines in guinea-pig trachealis smooth muscle cells. Br J Pharmacol 82:757–762

    Google Scholar 

  • Bryan LJ, Fleig H, Trendelenburg U (1983) A comparative study of the properties of the catechol-O-methyltransferase inhibitors, U-0521 and tropolone acetamide, in rat perfused heart. Naunyn-Schmiedeberg's Arch Pharmacol 322:6–19

    Google Scholar 

  • Fiebig ER, Trendelenburg U (1978) The kinetic constants for the extraneuronal uptake and metabolism of 3H-(−)-noradrenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 303:37–45

    Google Scholar 

  • Furchgott RF, Sanchez Garcia P (1968) Effects of inhibition of monoamine oxidase on the actions and interactions of norepinephrine, tyramine and other drugs on guinea-pig left atrium. J Pharmacol Exp Ther 163:98–122

    Google Scholar 

  • Gillis CN (1976) Extraneuronal transport of noradrenaline in the lung. In: Paton DM (ed) The mechanism of neuronal and extraneuronal transport of catecholamines. Raven Press, New York, pp 281–297

    Google Scholar 

  • Graefe KH, Stefano FJE, Langer SZ (1973) Preferential metabolism of (−)-3H-norepinephrine through the deaminated glycol in the rat vas deferens. Biochem Pharmacol 22:1147–1160

    Google Scholar 

  • Grohmann M, Trendelenburg U (1983) The isotope effect of tritium in 3H-(−)-adrenaline with very high specific activity. Naunyn-Schmiedeberg's Arch Pharmacol 324:233–234

    Google Scholar 

  • Grohmann M, Trendelenburg U (1984) The substrate specificity of uptake2 in the rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 328:164–173

    Google Scholar 

  • Grohmann M, Trendelenburg U (1985) The handling of five catecholamines by the extraneuronal O-methylating system of the rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 329: 264–270

    Google Scholar 

  • Grohmann M, Henseling M, Cassis L, Trendelenburg U (1986) The errors introduced by a tritium label in position 8 of catecholamines. Naunyn-Schmiedeberg's Arch Pharmacol 332:34–42

    Google Scholar 

  • Guimaraes S, Trendelenburg U (1985) Deviation supersensitivity and inhibition of saturable sites of loss. TIPS 6:371–374

    Google Scholar 

  • Henseling M (1983) Kinetic constants for uptake and metabolism of 3H-(−)-noradrenaline in rabbit aorta. Possible falsification of the constants by diffusion barriers within the vessel wall. Naunyn-Schmiedeberg's Arch Pharmacol 323:12–23

    Google Scholar 

  • Henseling M (1984) Stereoselectivity of extraneuronal uptake of catecholamines in rabbit aorta. Naunyn-Schmiedeberg's Arch Pharmacol 328:219–220

    Google Scholar 

  • Kurahashi K, Rawlow A, Trendelenburg U (1980) A mathematical model representing the extrancuronal O-methylating system of the perfused rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 311:17–32

    Google Scholar 

  • Paton DM (1973) Evidence for carrier-mediated efflux of noradrenaline from the axoplasm of adrenergic nerves in rabbit atria. J Pharm Pharmacol 25:265–267

    Google Scholar 

  • Sammet S, Graefe KH (1979) Kinetic analysis of the interaction between noradrenaline and Na+ in neuronal uptake: kinetic evidence for co-transport. Naunyn-Schmiedeberg's Arch Pharmacol 309:99–107

    Google Scholar 

  • Sanchez-Armass S, Orrego F (1978) Noradrenalie transport by rat heart sympathetic nerves: a re-examination of the role of sodium isons. Naunyn-Schmiedeberg's Arch Pharmacol 302:255–261

    Google Scholar 

  • Simmonds MA, Gillis CN (1968) Uptake of normetanephrine and norepinephrine by cocaine-treated rat heart. J Pharmacol Exp Ther 159:283–289

    Google Scholar 

  • Starke K, Steppeler A, Zumstein A, Henseling M, Trendelenburg U (1980) False labelling of commercially available 3H-catecholamines? Naunyn-Schmiedeberg's Arch Pharmacol 311:109–112

    Google Scholar 

  • Stefano FJE, Trendelenburg U (1984) Saturation of monoamine oxidase by intraneuronal noradrenaline accumulation. Naunyn-Schmiedeberg's Arch Pharmacol 328:135–141

    Google Scholar 

  • Trendelenburg U (1980) A kinetic analysis of extraneuronal uptake and metabolism of catecholamines. Rev Physiol Biochem Pharmacol 87:33–115

    Google Scholar 

  • Trendelenburg U (1984a) The influence of inhibition of catechol-O-methyl transferase or of monoamine oxidase on the extraneuronal metabolism of 3H-(−)-noradrenaline in the rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 327:285–292

    Google Scholar 

  • Trendelenburg U (1984b) Metabolizing systems. In: Fleming WW, Langer SZ, Graefe KH, Weiner N (eds) Neuronal and extraneuronal events in autonomic pharmacology. Raven Press, New York, pp 93–109

    Google Scholar 

  • Trendelenburg U (1985) The outward transport of catecholamines by uptake2 of the rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 330:203–211

    Google Scholar 

  • Trendelenburg U, Fleig H, Bryan LJ, Bönisch H (1983a) The extraneuronal compartments for the distribution of isoprenaline in the rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 324: 169–179

    Google Scholar 

  • Trendelenburg U, Stefano FJE, Grohmann M (1983b) The isotope effect of tritium in 3H-noradrenaline. Naunyn-Schmiedeberg's Arch Pharmacol 323:128–140

    Google Scholar 

  • Uhlig W, Fiebig R, Trendelenburg U (1976) The effect of corticosterone on the fluxes of 3H-normetanephrine into and out of the extraneuronal compartments of the perfused rat heart. Naunyn-Schmiedeberg's Arch Pharmacol 295:45–50

    Google Scholar 

  • Wilbrandt W, Rosenberg T (1961) The concept of carrier transport and its corollaries in pharmacology. Pharmacol Rev 13:109–183

    Google Scholar 

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Trendelenburg, U. The metabolizing systems involved in the inactivation of catecholamines. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, 201–207 (1986). https://doi.org/10.1007/BF00504854

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