Production of itaconic acid by Aspergillus terreus immobilized in polyacrylamide gels

  • Hiroyuki Horitsu
  • Yasushi Takahashi
  • Junkō Tsuda
  • Keiichi Kawai
  • Yoshio Kawano
Biotechnology

Summary

Living Aspergillus terreus cells were entrapped in polyacrylamide gels and employed in both replacement batch and continuous column reactors to produce itaconic acid from glucose.

With the replacement batch reactor, maximum itaconic acid productivity was observed under the following conditions: pH 2.50, temperature at 35°C, addition of NH4H2PO4 and MgSO4·7H2O. Using the continuous reactor, the maximum itaconic acid yield was 60 mg/h/40 g of gel. The biocatalyst activity or half-life was about 10 days.

Keywords

Glucose Polyacrylamide MgSO4 Aspergillus Acid Productivity 

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References

  1. Calam CT, Oxford AE, Raistrick H (1939) The biochemistry of microorganisms LXIII. Itaconic acid, a metabolic product of a strain of Aspergillus terreus Thom. Biochem J 33:1488–1495Google Scholar
  2. Kinoshita K (1929) Production of itaconic acid and mannitol by Aspergillus itaconicus. J Chem Soc Japan 50:583–593Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Hiroyuki Horitsu
    • 1
  • Yasushi Takahashi
    • 1
  • Junkō Tsuda
    • 1
  • Keiichi Kawai
    • 1
  • Yoshio Kawano
    • 2
  1. 1.Department of Agricultural ChemistryGifu UniversityGifuJapan
  2. 2.Iwata Chemical Industry Co., LTDIwata, ShizuokaJapan

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