Summary
The influence of halothane, chloroform and propanidid on hexokinase, phosphoglucose-isomerase and phosphofructokinase was studied in vitro. None of the three anaesthetic agents significantly inhibited the activity of hexokinase or phosphoglucose-isomerase preparations.
A significant inhibition of phosphofructokinase was brought about by halothane, chloroform and propanidid.
The inhibitory effect proved to be dependent upon the concentration of the anaesthetic drugs. It is unlikely that the resulting weak inhibition of glycolysis is causally related to the acute cardiodepressive action of the anaesthetic agents studied. However, the inhibition of glucose oxidation by halothane and other potent anaesthetic agents might be harmful after prolonged exposure, especially since significant accumulation in cardiac and other tissues occurs.
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References
Bergmeyer, H. U. (Ed.): Methoden der enzymatischen Analyse. Weinheim: Verlag Chemie 1970
Ko, K. C., Paradise, R. R.: The effects of substrates on contractility of rat atria depressed with halothane. Anesthesiology 31, 532–539 (1969)
Ko, K. C., Paradise, R. R.: The effect of fructose on halothane-depressed rat atria. Anesthesiology 32, 124–129 (1970a)
Ko, K. C., Paradise, R. R.: The effects of substrates on halothane-depressed isolated human atria. Anesthesiology 33, 508–514 (1970b)
Ko, K. C., Paradise, R. R.: Contractile depression of rat atria by halothane in the absence of glucose. Anesthesiology 34, 152–156 (1971a)
Ko, K. C., Paradise, R. R.: The effect of halothane on the contractility of atria from starved rats. Anesthesiology 34, 557–561 (1971b)
Porsius, A. J.: Ph. D. Thesis, University of Amsterdam, 1973
Porsius, A. J., van Zwieten, P. A.: The influence of halothane on calcium uptake by isolated cell membranes. J. Pharm. Pharmacol. 25, 760–761 (1973a)
Porsius, A. J., van Zwieten, P. A.: Quantitative evaluation of the cardiodepressive action of halothane and some related drugs in isolated heart muscle. Comparison with in vivo circumstances. Arch. int. Pharmacodyn. 205, 134–143 (1973b)
Salas, M. L., Viñuela, E., Salas, M., Sols, A.: Citrate inhibition of phosphofructokinase and the Pasteur effect. Biochem. biophys. Res. Commun. 19, 371–376 (1965)
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Porsius, A.J., van Zwieten, P.A. Anaesthetic agents and glycolysis. Naunyn-Schmiedeberg's Arch. Pharmacol. 284, 399–402 (1974). https://doi.org/10.1007/BF00504709
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DOI: https://doi.org/10.1007/BF00504709