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Postmortal accumulation of 3-methoxytyramine in brain

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Summary

Rats were decapitated and the brains stored in situ at +37° C. A rapid accumulation of 3-methoxytyramine occurred during the first hour. The accumulation was enhanced by pargyline pretreatment. It was less rapid at lower temperatures.

The postmortal loss of dopamine corresponded to the formation of methoxytyramine in the pargyline-treated rats but exceeded this formation in non-treated rats.

Large amounts of methoxytyramine were also recovered from the basal ganglia of two human brains.

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Author notes

  1. W. Kehr

    Present address: Schering AG, Postfach 650311, D-1000, Berlin 65, Germany

Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, Fack, S-400 33, Göteborg 33, Sweden

    A. Carlsson, M. Lindqvist & W. Kehr

Authors
  1. A. Carlsson
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  2. M. Lindqvist
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  3. W. Kehr
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Carlsson, A., Lindqvist, M. & Kehr, W. Postmortal accumulation of 3-methoxytyramine in brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 284, 365–372 (1974). https://doi.org/10.1007/BF00504705

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  • DOI: https://doi.org/10.1007/BF00504705

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