Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 314, Issue 2, pp 191–193 | Cite as

Peristalsis in the isolated guinea-pig ileum during opiate withdrawal

  • W. Kromer
  • R. Woinoff


Naloxone enhances peristalsis in isolated intestinal segments from morphine-dependent guinea-pigs to a greater degree than in naive preparations. These data suggest that a peripheral mechanism may be involved in the expression of opiate withdrawal in the small intestine, and indicate that the action of this mechanism leads, at least in vitro, to an increase in the number of peristaltic waves.

Key words

Opiate withdrawal Naloxone Intestinal peristalsis 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • W. Kromer
    • 1
  • R. Woinoff
    • 2
  1. 1.Pharmakologisches Institut der Universität MünchenMünchen 2Federal Republic of Germany
  2. 2.Neuropharmakologische AbteilungMax-Planck-Institut für PsychiatrieMünchen 40Federal Republic of Germany

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