Abstract
An electrophoretically detectable variant of lactate dehydrogenase-2 in Mus musculus has been found and used to locate the structural gene, Ldh-2, on chromosome 6. Gene order and recombination frequencies are estimated as Sig—36.0±4.8—Lc 21.0±4.1—Mi wh—20.0±4.0—Ldh-2.
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Berry, R. J., and Peters, J. (1981). Allozymic variation in house mouse populations. In Smith, M. H., and Joule, J. (eds.), Mammalian Population Genetics University of Georgia Press, Athens, pp. 242–253.
Britton-Davidian, J., Bustos, A. R., Thaler, L., and Topal, M. (1978). Lactate dehydrogenase polymorphism in Mus musculus L. and Mus spretus Lataste. Experientia 341144.
Buckle, V. J., Edwards, J. H., Evans, E. P., Jonasson, J. A., Lyon, M. F., Peters, J., Searle, A. G., and Wedd, N. S. (1984). Chromosome maps of man and mouse II. Clin. Genet. 261.
Charles, D. I., and Prestch, W. (1981). A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. I. Genetical and electrophoretical characterization. Biochem. Genet. 19301.
Davisson, M. T., and Roderick, T. H. (1981). Recombination percentages. In Green, M. C. (ed.), Genetic Variants and Strains of the Laboratory Mouse Gustav Fischer Verlag, New York, pp. 283–313.
George, D. L., de Martinville, B., and Francke, U. (1984). Amplified DNA sequences, including a c-ki-ras oncogene present in Y1 mouse adrenal tumor cells originate from mouse chromosome 6. Cytogenet. Cell Genet. 37447.
Goldberg, E. (1977). Isozymes in testes and spermatozoa. In Ratuzzi, M. C., Scandalios, J., and Whitt, G. S. (eds.), Isozymes: Current Topics in Biological and Medical Research Alan R. Liss, New York, Vol. 1, pp. 79–124.
Hutton, J. J., and Roderick, T. H. (1970). Linkage analyses using biochemical variants in mice. III. Linkage relationships of eleven biochemical markers. Biochem. Genet. 4339.
Jongsma, A. P. M., Los, W. R. T., and Hagemeijer, A. (1974). Evidence for synteny between the human loci for triose phosphate isomerase, lactate dehydrogenase-B, and peptidase B and the regional mapping of these loci on chromosome 12. Cytogenet. Cell Genet. 13106.
Khlebodarova, T. M., and Serov, O. L. (1980). A new locus regulating the expression of the Ldh-2 gene in mouse liver. Biochem. Genet. 181027.
Law, M. L., and Kao, F.-T. (1982). Regional mapping of the gene coding for enolase-2 on human chromosome 12. J. Cell Sci. 53245.
Leinwand, L. A., Kozak, C. A., and Ruddle, F. H. (1978). Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization. Somat. Cell Genet. 4233.
Markert, C. L., Shaklee, J. B., and Whitt, G. S. (1975). Evolution of a gene. Science 189102.
Meistrich, M. L., Trostle, P. K., Frapart, M., and Erickson, R. P. (1977). Biosynthesis and localization of lactate dehydrogenase X in pachytene spermatocytes and spermatids of mouse testis. Dev. Biol. 60428.
Minna, J. D., Bruns, G. A. P., Krinsky, A. H., Lalley, P. A., Francke, U., and Gerald, P. S. (1978). Assignment of a Mus musculus gene for triosephosphate isomerase to chromosome 6 and for glyoxalase-1 to chromosome 17 using somatic cell hybrids. Somat. Cell Genet. 4241.
Nadeau, J. H., and Taylor, B. A. (1984). Lengths of chromosomal segments conserved since divergence of man and mouse. Proc. Natl. Acad. Sci. USA 81814.
Peters, J., and Bulfield, G. (1984). Personal communication. Mouse News Lett. 7082.
Roderick, T. H., Lalley, P. A., Davisson, M. T., O'Brien, S. J., Womack, J. E., Créau-Goldberg, N., Echard, G., and Moore, K. L. (1984). Report of the committee on comparative mapping. Cytogenet. Cell Genet. 37312.
Sakaguchi, A. Y., Zabel, B. U., Grzeschik, K. H., Law, M. L., and Naylor, S. L. (1984a). Human proto-oncogene assignments. Cytogenet. Cell Genet. 37572.
Sakaguchi, A. Y., Lalley, P. A., Zabel, B. U., Ellis, R., Scolnick, E., and Naylor, S. L. (1984b). Mouse proto-oncogene assignments. Cytogenet. Cell Genet. 37573.
Shows, T. B., and Ruddle, F. H. (1968). Function of the lactate dehydrogenase B gene in mouse erythrocytes: Evidence for control by a regulatory gene. Proc. Natl. Acad. Sci. USA 61574.
Soares, E. R. (1978). Personal communication. Mouse News Lett. 5912.
Soares, E. R. (1979). TEM-induced gene mutations at enzyme loci in the mouse. Environ. Mutagen. 119.
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Peters, J., Andrews, S.J. Linkage of lactate dehydrogenase-2, Ldh-2, in the mouse. Biochem Genet 23, 217–225 (1985). https://doi.org/10.1007/BF00504320
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DOI: https://doi.org/10.1007/BF00504320