Abstract
Genetic analysis of backcross progeny from previously characterized rat inbred strains revealed that the biochemical marker Lap-1 is localized in linkage group I (LG I). Lap-1 codes for leucine arylaminopeptidase (EC 3.4.11). The distances of Lap-1 to c, RT6, and Hbb, based on recombination frequencies, are 3.1±1.5, 8.3±4.0, and 11.4±2.8 cM, respectively. Acon-1 codes for aconitase (EC 4.2.1.3). The calculated distances of Acon-1 to c and Hbb are 30.1±5.0 and 36.1±5.3 cM, respectively. This suggests that Acon-1 is also in LG I, but the observed high frequency of double crossovers requires further confirmation of this linkage. Ahd-2, Es-6, and Gdc-1 are linked neither to markers of LG I nor to one another.
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van Zutphen, L.F.M., den Bieman, M., Hedrich, H.J. et al. Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus). Biochem Genet 23, 599–606 (1985). https://doi.org/10.1007/BF00504294
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DOI: https://doi.org/10.1007/BF00504294