Advertisement

Biochemical Genetics

, Volume 19, Issue 9–10, pp 1023–1030 | Cite as

Genetic variation of milk proteins in mice

  • John E. Piletz
  • Roger E. Ganschow
Article

Abstract

A survey for qualitative and quantitative variation in milk proteins from 58 inbred strains of mice revealed two electrophoretic variants. One is in a whey acidic protein of milk of YBR mice and the other is in a curd protein of the Asian house mouse, Mus musculus castaneus. The whey acidic protein variant is shown to be under the control of a single Mendelian autosomal gene with alleles expressed in a codominant manner. This gene is designated Wap, is not identical to Eg, is not X linked, and is either unlinked or loosely linked to the coat color genes a and b.

Key words

milk mouse whey casein electrophoretic variant 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bezkorovainy, A. (1965). Comparative study of the acid glycoproteins isolated from bovine serum, colostrum and milk whey. Arch. Biochem. Biophys. 110558.Google Scholar
  2. Chapman, V. M., Paigen, K., Siracusa, L., and Womack, J. (1979). Biochemical variation: mouse. In Altman, P. L., and Katz, D. D. (eds.), Inbred and Genetically Defined Strains of Laboratory Animals Federation of American Societies for Experimental Biology, Bethesda, Md., pp. 77–95.Google Scholar
  3. Farrell, H. M., and Thompson, M. P. (1971). Biological significance of milk protein polymorphism. J. Dairy Sci. 541219.Google Scholar
  4. Feldman, M. K., and Hohmann, P. (1971). Identification of mouse casein components following immunodiffusion and electrophoretic analysis. Int. J. Biochem. 2477.Google Scholar
  5. Gordon, W. G., and Ziegler, J. (1955). Biochemical preparations. In Westerfield, W. W. (ed.) α-Lactalbumin, Vol. 4 Wiley, New York, p. 16.Google Scholar
  6. Green, M. R., and Pastewka, J. V. (1976). Characterization of major milk proteins from Balb/c and C3H mice. J. Dairy Sci. 59207.Google Scholar
  7. Grosclaude, F., Mahe, M.-F., Mercier, J. C., Bonnemarie, J., and Teissier, J. H. (1976). Lacto-protein polymorphism in Nepalese bovinae. 1. Evidence in the yak and biochemical characterization of 2 new variants, beta-lactoglobulin D-Yak and alpha-S-1 casein E. Ann. Genet. Sel. Anim. 8461.Google Scholar
  8. Grosclaude, F., Joudrier, P., and Mahe, M.-F. (1979). A genetic and biochemical analysis of a polymorphism of bovine alpha-S-2 casein. J. Dairy Res. 46211.Google Scholar
  9. Hjorth, P. J. (1979). Genetic variation in mouse salivary amylase rate of synthesis. Biochem. Genet. 17655.Google Scholar
  10. Jenness, R. (1974). The composition of milk. In Larson, B. L., and Smith, V. R. (eds.), Lactation, A Comprehensive Treatise, Vol. III Academic Press, New York, pp. 3–96.Google Scholar
  11. Lowry, O. H., Rosebrough, N. J., Farr, R. J., and Randall, R. J. (1951). Protein measurements with the Folin phenol reagent. J. Biol. Chem. 193265.Google Scholar
  12. Lusis, A., Tomino, S., and Paigen, K. (1976). Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding. J. Biol. Chem. 2517753.Google Scholar
  13. McBurney, J. J., Meir, H., and Hoag, W. G. (1964). Device for milking mice. J. Lab. Clin. Med. 64485.Google Scholar
  14. McKenzie, H. A., (ed.) (1971). Milk Proteins, Vols. I and II Academic Press, New York.Google Scholar
  15. McKenzie, R. M., and Larson, B. L. (1978). Purification and partial characterization of a unique group of phosphoproteins from rat milk whey. J. Dairy Sci. 61723.Google Scholar
  16. Pastewka, J. V., Reed, R. A., Ness, A. T., and Peacock, A. C. (1973). An improved haptoglobin subtyping procedure using polyacrylamide gel electrophoresis. Anal. Biochem. 51152.Google Scholar
  17. Piletz, J. E., and Ganschow, R. E. (1978). Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Science 199181.Google Scholar
  18. Thompson, M. P., and Farrell, H. M., Jr. (1974). Genetic variants of the milk proteins. In Larson, B. L., and Smith, V. R. (eds.), Lactation, A Comprehensive Treatise, Vol. III Academic Press, New York, pp. 109–132.Google Scholar

Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • John E. Piletz
    • 1
  • Roger E. Ganschow
    • 1
  1. 1.The Children's Hospital Research Foundation and the Department of Pediatrics of the University of Cincinnati College of MedicineCincinnati

Personalised recommendations