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Effects of anticonvulsants and methotrexate on calcium disposition

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Summary

Administration of phenytoin for 5 days significantly reduces oral absorption and bone uptake of radiolabelled calcium in mice. Acute treatment with phenytoin had no effect on calcium disposition. Pretreatment (1–5 days) with phenobarbital also had no effect of calcium disposition. Methotrexate pretreatment for 5 days increased the bone uptake of radiolabelled calcium presumably by decreasing calcium renal clearance. It is concluded that phenytoin induced reduction in calcium metabolism is unrelated to a state of functional folate deficiency.

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Abbreviations

25(OH)D:

25-Hydroxyvitamin D

1,25(OH)2D:

1,25-dihydroxyvitamin D

PB:

Phenobarbital sodium

MTX:

Methotrexate

DPH:

Phenytoin

Ca-45:

Calcium-45

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Authors and Affiliations

  1. Department of Pharmacology, University of Illinois at the Medical Center, 60680, Chicago, Illinois, USA

    Michael A. Evans

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  1. Michael A. Evans
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Evans, M.A. Effects of anticonvulsants and methotrexate on calcium disposition. Naunyn-Schmiedeberg's Arch. Pharmacol. 315, 63–67 (1980). https://doi.org/10.1007/BF00504231

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  • DOI: https://doi.org/10.1007/BF00504231

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