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Analogs of pyrimidine nucleosides. 14. Synthesis and antitumorigenic activity of alkoxyalkyl derivatives of 5-fluorouracil

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers. It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis. The UV and NMR spectra of the synthesized compounds are presented.

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Authors and Affiliations

  1. Institute of Molecular Biology, Academy of Sciences of the USSR, 117334, Moscow

    M. Ya. Karpeiskii, S. M. Mikhailov, A. S. Tsieminya, A. A. Ziderman, I. M. Kravchenko, M. Yu. Lidak & R. A. Zhuk

  2. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    M. Ya. Karpeiskii, S. M. Mikhailov, A. S. Tsieminya, A. A. Ziderman, I. M. Kravchenko, M. Yu. Lidak & R. A. Zhuk

Authors
  1. M. Ya. Karpeiskii
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  2. S. M. Mikhailov
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  3. A. S. Tsieminya
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  4. A. A. Ziderman
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  5. I. M. Kravchenko
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  6. M. Yu. Lidak
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  7. R. A. Zhuk
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Additional information

See [9] for Communication 13.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1541–1544, November, 1980.

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Karpeiskii, M.Y., Mikhailov, S.M., Tsieminya, A.S. et al. Analogs of pyrimidine nucleosides. 14. Synthesis and antitumorigenic activity of alkoxyalkyl derivatives of 5-fluorouracil. Chem Heterocycl Compd 16, 1176–1179 (1980). https://doi.org/10.1007/BF00504118

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  • DOI: https://doi.org/10.1007/BF00504118

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