Abstract
1-Alkoxy-2,2-bis(trifluoromethyl)aziridines containing an ester group in the α position of the alkoxy substituent undergo nucleophilic substitution (ammonolysis and hydrolysis) with retention of the aziridine ring. The corresponding carboxylic acids, which were separated to give the antipodes with an optical purity of 95% through the diastereomeric salts with R- and S-α-phenylethylamine, were obtained.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1495–1500, November, 1980.
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Kostyanovskii, R.G., Kadorkina, G.K., Chervin, I.I. et al. Optically active 1-Alkoxy-2,2-bis(trifluoromethyl)aziridines. Chem Heterocycl Compd 16, 1133–1139 (1980). https://doi.org/10.1007/BF00504109
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DOI: https://doi.org/10.1007/BF00504109