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Antiporphyric activity of thiophene-2-carboxylic acid in allylisopropylacetamide-treated rats

  • A. Pinelli
  • A. Capuano
  • M. Bellei
Short Communication

Summary

Allylisopropylacetamide (AIA) administration to rats increases δ-aminolevulinic acid (ALA) synthetase activity and porphyrin levels in liver.

Thiophene-2-carboxylic acid in AIA-treated rats markedly decreases liver ALA synthetase and porphyrin values. Thiophene-2-carboxylic acid exerts a protective effect against porphyria experimentally induced by AIA administration.

Key words

Thiophene-2-Carboxylic Acid Protection Allylisopropylacetamide Porphyria Rats 

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References

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • A. Pinelli
    • 1
    • 2
  • A. Capuano
    • 1
    • 2
  • M. Bellei
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of MilanItaly
  2. 2.Center for Occupational Diseases F. MarazziSassuolo (Modena)

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