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Oxidation of some derivatives of tetrahydropyrimidine-5-carboxylic acid with selenium dioxide

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The oxidation of derivatives of 2-oxo-4-phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid with selenium dioxide was studied. It was observed that the 6-methyl group is oxidized to a hydroxymethyl, formyl, or carboxy group (in the latter case probably after dehydrogenation of the ring). The structure of the final product depends on the degree of substitution of the ring with respect to the nitrogen atom and on the substituent in the 5 position.

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Literature cited

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, 226006, Riga

    E. L. Khanina & G. Ya. Dubur

Authors
  1. E. L. Khanina
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  2. G. Ya. Dubur
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 535–538, April, 1982.

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Khanina, E.L., Dubur, G.Y. Oxidation of some derivatives of tetrahydropyrimidine-5-carboxylic acid with selenium dioxide. Chem Heterocycl Compd 18, 412–414 (1982). https://doi.org/10.1007/BF00503565

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  • DOI: https://doi.org/10.1007/BF00503565

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