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Chemistry of Heterocyclic Compounds

, Volume 18, Issue 4, pp 385–390 | Cite as

Synthesis of 3-oxoisothiazolo[5,4-b] pyridines

  • A. A. Krauze
  • Z. A. Bomika
  • Yu. É. Pelcher
  • I. B. Mazheika
  • G. Ya. Dubur
Article

Abstract

3-Oxoisothiazolo[5,4-b]pyridines were synthesized for the first time by the reaction of 3-cyanopyridine-2-thiones or bis(3-cyanopyridyl) disulfides with concentrated sulfuric acid. It is demonstrated that 3-carbamoylpyridine-2-thiones are formed as intermediates. The 3-oxoisothiazolopyridines were converted to 3-bromoisothiazolopyridines and pyridine-2-thiones. The bromination of pyridine-2-thione was studied.

Keywords

Organic Chemistry Pyridine Sulfuric Acid Disulfide Concentrate Sulfuric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • A. A. Krauze
    • 1
  • Z. A. Bomika
    • 1
  • Yu. É. Pelcher
    • 1
  • I. B. Mazheika
    • 1
  • G. Ya. Dubur
    • 1
  1. 1.Institute of Organic SynthesisAcademy of Sciences of the Latvian SSRRiga

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