Biochemical Genetics

, Volume 17, Issue 7–8, pp 731–736 | Cite as

Cadmium metabolism in cdm/cdm mice

  • Miriam Meisler
  • Craig Orlowski
  • Ellen Gross
  • John H. Bloor
Article

Abstract

The uptake and metabolism of cadmium by cadmium-susceptible (+/+) and cadmium-resistant (cdm/cdm) strains of mice have been compared. These strains did not differ with respect to the quantitative uptake of cadmium into liver, kidney, or testis. After intraperitoneal administration of a nontoxic dose, more than 80% of the cadmium in liver and testis of both strains is bound to low molecular weight proteins. The chromatographic behavior of these cadmium-binding proteins is not affected by cdm genotype.

Key words

cadmium metallothionein testis genetic susceptibility 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Miriam Meisler
    • 1
  • Craig Orlowski
    • 1
  • Ellen Gross
    • 1
  • John H. Bloor
    • 2
  1. 1.Department of Human GeneticsUniversity of MichiganAnn Arbor
  2. 2.Department of BiochemistryState University of New York at BuffaloBuffalo

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