Extrarenal effects of aldosterone antagonists in guinea pigs

I. Enhanced transport of potassium into the cells
  • H. R. Mattern
  • W. Schaumann
Article

Summary

Renal and extrarenal effects of aldosterone antagonists on potassium balance were investigated in guinea pigs.
  1. 1.

    Pretreatment with 2×120 μmoles/kg spironolactone orally for 3 days increased the tissue: plasma ratio of potassium in cardiac and skeletal muscle. Plasma potassium was unchanged.

     
  2. 2.

    A single dose of 120 μmoles/kg spironolactone orally increased the urinary output of sodium. The renal excretion and clearance of potassium were unchanged.

     
  3. 3.

    In the isolated heart, perfusion with spironolactone or canrenone induced an uptake of potassium. Canrenoate-K and aldosterone were inactive.

     

It is concluded that in guinea pigs aldosterone antagonists favour a shift of potassium from the extra- to the intracellular space by a direct effect on cardiac and skeletal muscle.

Key words

Aldosterone Antagonists Extrarenal Effects Guinea Pig Potassium Transport 

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References

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • H. R. Mattern
    • 1
  • W. Schaumann
    • 1
  1. 1.Medizinische Forschung der Boehringer Mannheim GmbHMannheim(Germany)

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