Summary
A method is described for simultaneous determination of a drug and its metabolites in blood and bile of rats with intact enterohepatic circulation. The comparison with the respective data obtained in biliary fistula animals allows a statement on enterohepatic circulation of the drug, if the bile flow is identical in both groups.
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References
Abshagen, U., Bergmann, K. v., Rietbrock, N.: Evaluation of enterohepatic circulation after 3H-digoxin administration in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. (in press) (1972).
Lauterbach, F.: Enterale Resorption, biliäre Ausscheidung und enterohepatischer Kreislauf von Herzglykosiden bei der Ratte. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 247, 391–411 (1964).
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Rietbrock, N., Abshagen, U. A method for investigation of enterohepatic circulation. Naunyn-Schmiedeberg's Arch. Pharmacol. 274, 208–210 (1972). https://doi.org/10.1007/BF00501857
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DOI: https://doi.org/10.1007/BF00501857