Summary
3H-dopamine synthesis from l-3,5-3H-tyrosine was reduced in striatal slices of 40 days old rats treated during their early life with neuroleptics. Animals were first injected intra-utero with thioproperazine (5 mg/kg) or with the palmitic ester of pipotiazine (32 mg/kg); the thioproperazine-treated rats were then injected every day from day 1 to day 37; the animals injected with the long acting neuroleptic were injected once more with the drug on day 15 after birth.
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References
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Velley, L., Blanc, G., Tassin, J.P. et al. Inhibition of striatal dopamine synthesis in rats injected chronically with neuroleptics in their early life. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 97–102 (1975). https://doi.org/10.1007/BF00501817
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DOI: https://doi.org/10.1007/BF00501817