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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 291, Issue 4, pp 319–333 | Cite as

The different fatty acid composition of lecithins in the sacroplasmic reticulum vesicles and the membranes of adrenal chromaffin granules

  • H. Balzer
  • A. Rauf Khan
Article

Summary

Calcium transporting membranes of sarcoplasmic reticulum (SR) and amine transporting membranes of chromaffin granules (AG) isolated from different animal species (ox, rabbit and rat) show similar values for their phospholipid phases (0.5 μmole phospholipids/mg protein). The AG-membranes, however, contain higher lysolecithin (LPC) (10–11%) than the SR-membranes (2–6%).

In both types of membrane a characteristic distribution of fatty acids was found in the phosphatidylcholine (PC) fraction. In SR-membranes 18-carbon fatty acids are present in increasing order of unsaturation (18:0<18:1<18:2) and in AG-membranes in decreasing order (18:0>18:1>18:2).

The fatty acid composition of PCs specific of each membrane seems to be dependent on the presence of different endogenous lysolecithins and suggest a fatty acid turnover in both positions of the PC by the de-and re-acylation cycle.

The importance in membrane function with regard to the Ca2+transport of SR and the amine transport of AG membranes as related to the typical lipid phase is discussed.

Key words

Fatty acids Phosphatidylcholine Membranes Lipid phase Transport function 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • H. Balzer
    • 1
  • A. Rauf Khan
    • 1
  1. 1.Zentrum der Pharmakologie (Abt. I)Klinikum der Johann Wolfgang Goethe-UniversitätFrankfurt am Main 70Federal Republic of Germany

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