Advertisement

Histochemistry

, Volume 72, Issue 3, pp 453–457 | Cite as

Immunocytochemical demonstration of renin in the mouse and rat kidney after adrenalectomy

  • M. Davidoff
  • T. H. Schiebler
Article

Summary

Bilateral adrenalectomy in the mouse and rat is followed by a proliferation of renin-producing cells in the kidney, especially in the terminal segments of the afferent arteriole and in the interlobular arteries. The affected cells become larger, and their immune reaction for renin is decreased.

Keywords

Public Health Immune Reaction Renin Terminal Segment Afferent Arteriole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barajas L, Latta H (1963) The juxtaglomerular apparatus in adrenalectomized rats. Light and electron microscopic observations. Lab Invest 12:1046–1059Google Scholar
  2. Bargmann W (1978) Harn- und Geschlechtsapparat. In: Handbuch der mikroskopischen Anatomie des Menschen, Bd. VII/5. Springer, Berlin Heidelberg New YorkGoogle Scholar
  3. Bucher O, Kaissling B (1973) Morphologie des juxtaglomerulären Apparates. Verh Anat Ges 67:109–136Google Scholar
  4. Camilleri JP, Phat VN, Bariety J, Corvol P, Menard J (1980) Use of a specific antiserum for renin detection in human kidney. J Histochem Cytochem 28:1343–1346Google Scholar
  5. Davis JO, Freeman RH (1976) Mechanisms controlling renin release. Physiol Rev 56:1–56Google Scholar
  6. Dunihue FW, Boldosser WG (1969) Observation on the similarity of mesangial to juxtaglomerular cells. Lab Invest 12:1228–1240Google Scholar
  7. Edelman R, Hartroft PM (1961) Localization of renin in juxtaglomerular cells of rabbit and dog through the use of the fluorescent antibody technique. Circ Res 9:1069–1077Google Scholar
  8. Galen FX, Guyenne TT, Devaux C, Menard J, Cornol P, Bariety J, Camilleri JP, N'Goc PW (1980) Purification of human kidney renin and production of highly specific antibodies: application to direct radioimmunoassay of tissue and plasma renin. In: Gross F, Vogel G (eds) Enzymatic release of vasoactive peptides. Raven Press, New YorkGoogle Scholar
  9. Gross F, Brunner M, Ziegler M (1965) Renin-angiotensin system, aldosterone and sodium balance. Recent Prog Horm Res 21:119–167Google Scholar
  10. Kugler P (1981) Localization of aminopeptidase A (Angiotensinase A) in the rat and mouse kidney. Histochemistry 72:269–278Google Scholar
  11. Peter ST (1976) Ultrastructural studies on the secretory process in the epitheloid cells of the juxtaglomerular apparatus. Cell Tissue Res 168:45–53Google Scholar
  12. Peter ST, Lazar J, Gross F (1973) Untersuchungen der juxtaglomerulären Zellen bei adrenalektomierten Ratten. Verh Anat Ges 67:161–165Google Scholar
  13. Peter ST, Lazar J, Gross F, Forssmann WG (1974) Studies on the juxtaglomerular apparatus. II. Quantitative morphology after adrenalectomy. Cell Tissue Res 151:457–469Google Scholar
  14. Senarklens CF de, Pricam CE, Banichahi FD, Vallotton MV (1977) Renin synthesis, storage and releae in the rat: A morphological and biochemical study. Kidney Int 11:161Google Scholar
  15. Sternberger LA (1979) Immunocytochemistry. 2nd ed. Wiley, New YorkGoogle Scholar
  16. Sutherland LE (1970) A fluorescent antibody study of juxtaglomerular cells using the freeze substitution technique. Nephron 7:512–523Google Scholar
  17. Tanaka T, Gresik EW, Michelakis AM, Barka T (1980) Immunocytochemical localization of renin in kidneys and submandibular glands of SWR/J and C57BL/6J mice. J Histochem Cytochem 28:1113–1118Google Scholar
  18. Taugner CH, Poulsen K, Hackenthal E, Taugner R (1979) Immunocytochemical localization of renin in mouse kidney. Histochemistry 62:19–27Google Scholar
  19. Taugner R, Rix E (1980) Personal communicationGoogle Scholar
  20. Vacca LL, Abrahams SJ, Naftchi NE (1980) A modified peroxidase-antiperoxidase procedure for improved localization of tissue antigens: Localization of substance P in rat spinal cord. J Histochem Cytochem 28:297–307Google Scholar
  21. Wright FS, Briggs JP (1979) Feedback control of glomerular blood flow, pressure, and filtration rate. Physiol Rev 59:958–10006Google Scholar
  22. Zehr JE, Kurz KD, Seymour AA, Schultz HD (1980) Mechanisms controlling renin release. Adv Exp Med Biol 130:135–170Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • M. Davidoff
    • 1
  • T. H. Schiebler
    • 1
  1. 1.Institute of AnatomyUniversity of WürzburgWürzburgGermany

Personalised recommendations