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Archives of oto-rhino-laryngology

, Volume 231, Issue 2–3, pp 761–763 | Cite as

Untersuchungen zur Entstehung eines Karzinoms aus einer Epitheldysplasie des Kehlkopfes

  • K. Laniado
  • W. Mann
II. Teil: Sitzungsbericht Onkologie Klinik
  • 17 Downloads

Contribution to the pathogenesis of carcinoma after laryngeal epithelial dysplasia

Summary

Between 1967 and 1980 laryngeal leukoplakia was clinically diagnosed in 86 patients. Histology proved true invasive carcinoma in 18 patients. Epithelial dysplasia grade I was found in 32 patients, grade II in 25 and grade III (carcinoma in situ) in nine patients. Eight patients (14%) with dysplasia grade I and II developed subsequently into carcinoma in situ or true invasive carcinoma. The average time lapse between first biopsy and histologically verified carcinogenesis was 5.1 years. No correlation was found to the histological grading.

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Literatur

  1. Kleinsasser O (1963) Eine Analyse der Vorgeschichte von Kehlkopfkrebskranken. Z Laryngol Rhinol 42: 14Google Scholar
  2. Kleinsasser O (1963) Die Klassifikation und Differentialdiagnose der Epitheldysplasien der Kehlkopf Schleimhaut auf Grund histomorphologischer Merkmale. Z Laryngol Rhinol 42: 339Google Scholar
  3. Kleinsasser O (1963) Über den Krankheitsverlauf bei Epithelhyperplasien der Kehlkopfschleimhaut und die Entstehung von Karzinomen. Z Laryngol Rhinol 42: 541Google Scholar
  4. Kleinsasser O (1976) Mikrolaryngoskopie und endolaryngeale Mikrochirurgie. Schattauer, Stuttgart New YorkGoogle Scholar
  5. Sciferth LB, Glanz H (1971) Carcinoma in situ laryngis. Z Laryngol Rhinol 50: 827Google Scholar
  6. WHO (1978) Collaborating centre for oral precancerous lesions. Definition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surg 46: 518Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • K. Laniado
    • 1
  • W. Mann
    • 1
  1. 1.Freiburg

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