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Similarity between the effect of experimental congestion of the isolated perfused rat liver and the action of cytochalasin B

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Summary

Livers of rats were perfused with dextran solutions, containing no red cells. Changes in the dextran concentration due to water shifts between the intra- and extracellular space of the liver were recorded continuously by polarimetric measurement. Cytochalasin B causes an uptake of potassium and water, followed by a release of water and a spontaneously reversible release of potassium, while the liver weight increases. From these effects an uptake of dextran, probably by an endocytotic process, is concluded.

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  1. Abteilung Chemie, Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany

    Werner Jahn

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  1. Werner Jahn
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Jahn, W. Similarity between the effect of experimental congestion of the isolated perfused rat liver and the action of cytochalasin B. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 431–434 (1973). https://doi.org/10.1007/BF00501485

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  • DOI: https://doi.org/10.1007/BF00501485

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