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Relations between the effects of histamine, pheniramin and metiamide on spontaneous motility and the formation of cyclic AMP in the isolated rat uterus

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Summary

Histamine (5×10−6 to 10−3M) depressed the spontaneous motility of the isolated rat uterus in a dose-dependent manner. Under these conditions uterine cyclic AMP was raised up to 92%. Both effects, uterine relaxation and cyclic AMP accumulation after 2 min could be inhibited dose dependently by the H2-antihistaminic compound metiamide (1.7×10−6 M to 1.7×10−4 M). By contrast, the H1-antagonist pheniramin (4.4×10−5 M) was ineffective. It was concluded that the histamine-induced inhibition of rat uterine motility is mediated by cyclic AMP which is formed in response to stimulation of H2-histaminergic receptors.

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Authors and Affiliations

  1. Pharmakologisches Institut, Universität Erlangen-Nürnberg, Universitätsstraße 22, D-8520, Erlangen, Federal Republic of Germany

    P. Mitznegg, E. Schubert & W. Fuchs

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  1. P. Mitznegg
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  2. E. Schubert
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  3. W. Fuchs
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Mitznegg, P., Schubert, E. & Fuchs, W. Relations between the effects of histamine, pheniramin and metiamide on spontaneous motility and the formation of cyclic AMP in the isolated rat uterus. Naunyn-Schmiedeberg's Arch. Pharmacol. 287, 321–327 (1975). https://doi.org/10.1007/BF00501477

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  • DOI: https://doi.org/10.1007/BF00501477

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