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Acid base balance in relation to gastric acid secretion stimulated by histamine and pentagastrin in cats

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Summary

  1. 1.

    In anaesthetized gastric fistula cats gastric acid secretion and the following blood gases and acid base parameters were determined in the arterial blood and in the gastric venous drainage: pH, HCO −3 concentration, pCO2 and pO2.

  2. 2.

    During pentagastrin-stimulated gastric acid secretion HCO −3 concentration and pH rose in the gastric venous effluent and to a small extent in the arterial blood. The venous pO2 dropped.

  3. 3.

    During histamine-stimulated gastric acid secretion, in addition to the changes occurring during pentagastrin-stimulation, an initial drop in arterial pO2, HCO −3 concentration and pH was observed.

  4. 4.

    After pretreatment of the animals with phenoxybenzamine or mepyramine the effects of histamine in the arterial blood were abolished suggesting that a histamine-mediated release of catecholamines is responsible for these effects of histamine.

  5. 5.

    Inhibition of carbonic anhydrase by acetazolamide inhibited gastric acid secretion and produced a rise in pCO2 with a concomitant drop in pH.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Tübingen, Tübingen, Germany

    Margitta Albinus & K. -Fr. Sewing

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  1. Margitta Albinus
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  2. K. -Fr. Sewing
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Supported by the Deutsche Forschungsgemeinschaft.

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Albinus, M., Sewing, K.F. Acid base balance in relation to gastric acid secretion stimulated by histamine and pentagastrin in cats. Naunyn-Schmiedeberg's Arch. Pharmacol. 285, 325–335 (1974). https://doi.org/10.1007/BF00501462

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  • DOI: https://doi.org/10.1007/BF00501462

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