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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 326, Issue 4, pp 287–290 | Cite as

Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels

  • Elisabeth Mocaër-Cretet
  • Monique Prioux-Guyonneau
  • Fella Redjimi
  • Yves Cohen
  • Christian Jacquot
Article

Summary

The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug.

Key words

Tabernanthine Brain serotonin Hypobaric hypoxia 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Elisabeth Mocaër-Cretet
    • 1
  • Monique Prioux-Guyonneau
    • 1
  • Fella Redjimi
    • 1
  • Yves Cohen
    • 1
  • Christian Jacquot
    • 1
  1. 1.Laboratoire de PharmacologieFaculté de PharmacieChatenay-MalabryFrance

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