Summary
Glycocholate and other bile acids inhibit the response of isolated hepatocytes to phalloidin in a concentration dependent manner. It is suggested that the inhibition is due to a block of phalloidin uptake. This interaction might explain the high specificity of phalloidin for liver tissue.
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This paper was supported by the Deutsche Forschungsgemeinschaft
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Frimmer, M., Petzinger, E., Rufeger, U. et al. The role of bile acids in phalloidin poisoning. Naunyn-Schmiedeberg's Arch. Pharmacol. 301, 145–147 (1977). https://doi.org/10.1007/BF00501430
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DOI: https://doi.org/10.1007/BF00501430