Summary
Acetylsalicylic acid (ASA) was tested for its antithrombotic activity in the arterial system after prophylactic administration to rats, using a new standardized method. Damage of the vessel wall was produced by chilling a small segment of the left carotid artery.
Dose related, significant results were obtained after 3 mg/kg orally. If higher doses (10 and 30 mg/kg) are administered, the formation of non-occlusive thrombi is inhibited by 70–90% on the basis of thrombus weight.
As the frequency distributions show, there are significantly more zero-values in the ASA treated groups (total 50%) than in the control groups.
However, the incidence of occlusive thrombi was not changed by ASA.
The long-lasting effect of ASA in inhibition of platelet aggregation was confirmed. The formation of arterial thrombi is significantly inhibited after prophylactic administration of 30 and 10 mg/kg up to 48 h before initiation of thrombosis. After administration of 3 mg/kg orally, only insignificant effects were observed. Thus the duration of action depends on the dose used.
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Meng, K., Seuter, F. Effect of acetylsalicylic acid on experimentally induced arterial thrombosis in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 301, 115–119 (1977). https://doi.org/10.1007/BF00501425
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DOI: https://doi.org/10.1007/BF00501425