Summary
The bilateral intrastriatal injection of kainic acid (2 μg/caudate) caused a marked decrease in the activity of striatal dopamine-sensitive adenylate cyclase. This probable loss of target cells for dopamine was associated with a parallel decrease of the cGMP level in the cerebellar cortex, which was maximal (80% loss) by 24 h and prevented apomorphine from raising cerebellar cGMP levels. On the contrary harmaline and isoniazid both increased the levels of cerebellar cGMP in kainic-lesioned rats to the same extent as in control rats. The results indicate that dopamine mechanisms in the striatum are involved in the regulation of cerebellar cortex cGMP.
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Biggio, G., Corda, M.G., Casu, M. et al. Kainic acid-induced lesion of dopaminergic target cells in the striatum: Consequences on the dynamics of cerebellar cGMP. Naunyn-Schmiedeberg's Arch. Pharmacol. 304, 5–7 (1978). https://doi.org/10.1007/BF00501370
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DOI: https://doi.org/10.1007/BF00501370