Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 274, Issue 4, pp 357–374 | Cite as

The influence of blood flow and water net flux on the blood-to-lumen flux of tritiated water in the jejunum of the rat

  • D. Winne
Article

Summary

  1. 1.

    Anaesthetized rats were loaded with tritiated water and a jejunal loop was perfused with hypo-, iso-, and hypertonic buffered saline solutions. The blood flow, the disappearance rate (from the blood), and the appearance rate (in the intestinal lumen) were determined simultaneously.

     
  2. 2.

    A decrease of the blood flow from about 1.7 to 0.2 ml min−1g−1 wet tissue weight diminished both the appearance rate and the disappearance rate of tritiated water. An increase of the blood flow caused the reversed results; however, at high blood flow the appearance and disappearance rate did not reach the value measured in the experiments with decreasing blood flow.

     
  3. 3.

    A water net flux directed towards the blood retarded and towards the intestinal lumen accelerated the blood-to-lumen flux of tritiated water at low, intermediate, and high blood flow values.

     
  4. 4.

    The data were analysed by a modified four-compartment-model considering the variation of blood flow and water net flux. The water net flux influences the blood-to-lumen flux of tritiated water by solvent drag during the penetration through the epithelium and by changing the luminal concentration (e.g. dilution) as well as the blood flow rate in the capillaries near the epithelium.

     

Key words

Intestinal Blood Flow Blood-to-Lumen Flux Tritiated Water Solvent Drag Rat 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • D. Winne
    • 1
  1. 1.Pharmakologisches Institut der Universität TübingenTubingenGermany

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