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Lowering of kininogen in rat blood by catecholamines

Involvement of non-eosinophil granulocytes and selective inhibition by trasylol

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Summary

Catecholamines lower the kininogen content of rat blood in vivo and in vitro. Blood cells are required: these are neither erythrocytes, lymphocytes, eosinophils nor platelets but could be neutrophils or basophils.

The bovine protease inhibitor (Trasylol®) inhibits the effects of l-adrenaline in vivo and in vitro but fails to affect the action of cellulose sulfate on rat plasma kininogen by more than a small extent.

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References

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil

    A. M. Rothschild, R. S. B. Cordeiro & A. Castania

Authors
  1. A. M. Rothschild
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  2. R. S. B. Cordeiro
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  3. A. Castania
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Rothschild, A.M., Cordeiro, R.S.B. & Castania, A. Lowering of kininogen in rat blood by catecholamines. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 323–326 (1974). https://doi.org/10.1007/BF00501241

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  • DOI: https://doi.org/10.1007/BF00501241

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