Summary
To determine the existence of a specific dopamine uptake process in the cerebral cortex of the rat, the effects of desipramine and benztropine on 3H-dopamine uptake were investigated in homogenates obtained from tissues of shamoperated rats and of rats injected locally with 6-OH-dopamine in order to destroy noradrenergic terminals. The results were compared with those obtained with striatal and cerebellar homogenates. Desipramine inhibited completely 3H-dopamine uptake in the cerebellar cortex but only by 76% in the cerebral cortex of shamoperated rats. Furthermore, desipramine did not inhibit 3H-dopamine uptake in cerebral homogenates of rats pretreated with 6-OH-dopamine. However, the desipramine-resistant 3H-amine uptake was reduced by benztropine, a potent inhibitor of 3H-dopamine uptake in striatal homogenates. These results demonstrate the existence of a specific uptake of dopamine in the dopaminergic terminals of the rat cerebral cortex.
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Tassin, J.P., Thierry, A.M., Blanc, G. et al. Evidence for a specific uptake of dopamine by dopaminergic terminals of the rat cerebral cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 282, 239–244 (1974). https://doi.org/10.1007/BF00501232
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DOI: https://doi.org/10.1007/BF00501232