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Morphological changes in nucleoli of lymphocytes and their influencing by trimethazone, phenylbutazone, indometacin, and 6-mercaptopurine in albino rats with adjuvant-induced disease

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Summary

The incidence of diverse types of nucleoli in peripheral blood lymphocytes was established in albino rats with adjuvant-induced disease, either untreated or receiving trimethazone, phenylbutazone, indometacin, or 6-mercaptopurine. Apart from typical clinical symptoms, the adjuvant-induced disease was characterized by an increase in the number of active nucleoli in the lymphocytes present in the peripheral blood of the diseased animals. This increase was influenced by the administration of any of the drugs enumerated.

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Author notes

  1. Zbyněk Likovský

    Present address: Research Laboratory for Cell and Tissue Ultrastructure of the Czechoslovak Academy of Sciences, Albertov 4, 128 00, Praha 2, Czechoslovakia

Authors and Affiliations

  1. Research Institute for Pharmacy and Biochemistry, Prague

    Zbyněk Likovský, Jaroslava Grimová, Antonín Dlabač & Jan Hondlík

  2. Research Laboratory for Cell and Tissue Ultrastructure of the Czechoslovak Academy of Sciences, Prague

    Karel Smetana

Authors
  1. Zbyněk Likovský
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  2. Jaroslava Grimová
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  3. Antonín Dlabač
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  4. Jan Hondlík
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  5. Karel Smetana
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Likovský, Z., Grimová, J., Dlabač, A. et al. Morphological changes in nucleoli of lymphocytes and their influencing by trimethazone, phenylbutazone, indometacin, and 6-mercaptopurine in albino rats with adjuvant-induced disease. Naunyn-Schmiedeberg's Arch. Pharmacol. 276, 181–186 (1973). https://doi.org/10.1007/BF00501190

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  • DOI: https://doi.org/10.1007/BF00501190

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