Summary
Microinjections of muscimol, a GABA receptor agonist, into the periaqueductal gray matter (PAG) counteracted the antinociceptive effect of morphine in rats, as measured by the “tail-flick” method. Muscimol's effect was partially reversed by bicuculline.
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References
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Zambotti, F., Zonta, N., Parenti, M. et al. Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception. Naunyn-Schmiedeberg's Arch. Pharmacol. 318, 368–369 (1982). https://doi.org/10.1007/BF00501180
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DOI: https://doi.org/10.1007/BF00501180