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The effects of harmine on the transmembrane action potentials of guinea-pig left atria as compared to those of quinidine

  • H. Iven
  • G. Zetler
Article

Summary

The actions of quinidine (7.7 and 25.5 μM) and harmine (10,33 and 66 μM) on the action potential of isolated guinea-pig atria were studied. Both substances prolonged repolarization time dose-dependently. The depolarization velocity was considerably reduced by quinidine, while it was comparatively little affected by harmine. Antiarrhythmic compounds of the harmine type are rare.

The effects on the action potential explain the differences between quinidine and harmine with regard to effects on the ECG and antagonism of aconitine-induced arrhythmia.

Key words

Antiarrhythmic Compounds Action Potential Harmine Heart Quinidine 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • H. Iven
    • 1
  • G. Zetler
    • 1
  1. 1.Institut für Pharmakologie der Medizinischen Hochschule LübeckLübeckGermany

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