Summary
When rat superior cervical ganglia were incubated with dibutyryl cyclic-AMP their content of dopamine-β-hydroxylase increased approximately two-fold over a period of six hours. This effect was blocked by cycloheximide. The possibility is discussed that cyclic AMP may mediate the rise in ganglion dopamine-β-hydroxylase which occurs during increased sympathetic activity.
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References
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Keen, P., McLean, W.G. Effect of dibutyryl cyclic-AMP on levels of dopamine-β-hydroxylase in isolated superior cervical ganglia. Naunyn-Schmiedeberg's Arch. Pharmacol. 275, 465–469 (1972). https://doi.org/10.1007/BF00501134
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DOI: https://doi.org/10.1007/BF00501134