Summary
The protective effect of acetylsalicylic acid (ASA) against thrombosis was investigated in the jugular vein of rats at sites of endothelial trauma induced with a high energy output ruby laser. To examine quantitatively thrombus formation and the effects of ASA, the thrombi were dissected out of the jugular vein 4 h after the laser-induced injury and weighed accurately. The results obtained with this standardized and quantitative technique indicate that ASA has a significant protective effect against laser-induced thrombosis. Inhibition of thrombus growth occurred when ASA was orally administered in doses of 3 and 10 mg/kg simultaneously with the laser stimulus. Increasing the ASA to 30 and 100 mg/kg did not produce further inhibition. Administration of ASA 16 h before induction of thrombosis also markedly inhibited thrombus formation. ASA probably acts to inhibit thrombus formation by inhibiting platelet aggregation. Administration of ASA 24 h after induction of thrombosis did not significantly alter the size or weight of the thrombi, indicating that ASA is not able to produce thrombolysis.
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Meng, K., O'Dea, K. The protective effect of acetylsalicylic acid on laser-induced venous thrombosis in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 283, 379–388 (1974). https://doi.org/10.1007/BF00501111
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DOI: https://doi.org/10.1007/BF00501111