Advertisement

Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 274, Issue 1, pp 107–109 | Cite as

Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium

  • K. O. Ellis
  • S. H. Bryant
Short Communication

Summary

Dantrolene sodium, a skeletal muscle relaxant, inhibits the twitch response by direct action on the muscle. The action potentials from dantrolene sodium depressed muscles have been examined by taking their first derivative, and membrane capacitance has been measured with cable analysis techniques. It is concluded that dantrolene sodium has no effect on the electrical excitability of the muscle and uncouples excitation-contraction mechanisms.

Key words

Dantrolene Sodium Excitation-Contraction Uncoupling Action Potentials Membrane Capacitance Skeletal Muscle 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bryant, S. H.: Cable properties of external intercostal muscle fibres from myotonic and nonmyotonic goats. J. Physiol. (Lond.) 204, 539 (1969).Google Scholar
  2. Chyatte, S. B., Birdsong, J. H., Bergman, B. A.: The effect of dantrolene sodium in spasticity and motor performance in hemiplegia. Sth. med. J. (Bgham, Ala.) 64, 180 (1971).Google Scholar
  3. Ellis, K. O., Carpenter, J. F.: The effects of dantrolene sodium (F-440) on skeletal muscle. Fed. Proc. 30, 670 (1971).Google Scholar
  4. Gage, P. W., Eisenberg, R. W.: Capacitance of the surface and transverse tubular membrane of frog sartorius muscle fibers. J. gen. Physiol. 53, 256 (1969).Google Scholar
  5. Honkomp, L. J., Halliday, R. P., Wessels, F. L.: Dantrolene, 1-[5-(p-nitrophenyl)-furfurylidene]amino hydantoin, a unique skeletal muscle relaxant. Pharmacologist 12, 301 (1970).Google Scholar
  6. Ross, S. M., Brust, M.: A transistorized pulse amplifier for massive stimulation of muscle. J. appl. Physiol. 20, 354 (1965).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • K. O. Ellis
    • 1
  • S. H. Bryant
    • 2
  1. 1.Research and Development DepartmentNorwich Pharmacal CompanyNorwich
  2. 2.Department of Pharmacology, College of MedicineUniversity of CincinnatiCincinnati

Personalised recommendations