Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium
- 164 Downloads
Dantrolene sodium, a skeletal muscle relaxant, inhibits the twitch response by direct action on the muscle. The action potentials from dantrolene sodium depressed muscles have been examined by taking their first derivative, and membrane capacitance has been measured with cable analysis techniques. It is concluded that dantrolene sodium has no effect on the electrical excitability of the muscle and uncouples excitation-contraction mechanisms.
Key wordsDantrolene Sodium Excitation-Contraction Uncoupling Action Potentials Membrane Capacitance Skeletal Muscle
Unable to display preview. Download preview PDF.
- Bryant, S. H.: Cable properties of external intercostal muscle fibres from myotonic and nonmyotonic goats. J. Physiol. (Lond.) 204, 539 (1969).Google Scholar
- Chyatte, S. B., Birdsong, J. H., Bergman, B. A.: The effect of dantrolene sodium in spasticity and motor performance in hemiplegia. Sth. med. J. (Bgham, Ala.) 64, 180 (1971).Google Scholar
- Ellis, K. O., Carpenter, J. F.: The effects of dantrolene sodium (F-440) on skeletal muscle. Fed. Proc. 30, 670 (1971).Google Scholar
- Gage, P. W., Eisenberg, R. W.: Capacitance of the surface and transverse tubular membrane of frog sartorius muscle fibers. J. gen. Physiol. 53, 256 (1969).Google Scholar
- Honkomp, L. J., Halliday, R. P., Wessels, F. L.: Dantrolene, 1-[5-(p-nitrophenyl)-furfurylidene]amino hydantoin, a unique skeletal muscle relaxant. Pharmacologist 12, 301 (1970).Google Scholar
- Ross, S. M., Brust, M.: A transistorized pulse amplifier for massive stimulation of muscle. J. appl. Physiol. 20, 354 (1965).Google Scholar