Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 274, Issue 1, pp 107–109 | Cite as

Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium

  • K. O. Ellis
  • S. H. Bryant
Short Communication


Dantrolene sodium, a skeletal muscle relaxant, inhibits the twitch response by direct action on the muscle. The action potentials from dantrolene sodium depressed muscles have been examined by taking their first derivative, and membrane capacitance has been measured with cable analysis techniques. It is concluded that dantrolene sodium has no effect on the electrical excitability of the muscle and uncouples excitation-contraction mechanisms.

Key words

Dantrolene Sodium Excitation-Contraction Uncoupling Action Potentials Membrane Capacitance Skeletal Muscle 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • K. O. Ellis
    • 1
  • S. H. Bryant
    • 2
  1. 1.Research and Development DepartmentNorwich Pharmacal CompanyNorwich
  2. 2.Department of Pharmacology, College of MedicineUniversity of CincinnatiCincinnati

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