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The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4′-dihydroxydiphenyl-(pyridyl-2)-methane

  • W. Forth
  • G. Nell
  • W. Rummel
  • H. Andres
Article

Summary

The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4′-dihydroxydiphenyl-(pyridyl-2)-methane was investigated in rats. In contrast to the free diphenol, the sulfuric acid ester did not show any hydragogue or absorptive inhibiting effect in colon segments of fasted rats, i.e. in the absence of feces in the colon. In fed rats, i.e. in the presence of feces in the colon, however, a dose of the sulfuric acid ester as low as 0.5 mg/segment diminishes the absorption of water significantly. The absorption of water in the rat colon was completely inhibited by 2 mg of the sulfuric acid ester persegment.

The sulfuric acid ester is split by microorganisms in the feces of rats and, thus, the free diphenol is liberated. It can be shown by in vitro incubation of the sulfuric acid ester in the presence of rat feces that free diphenol appears. The resulting amount is sufficient to inhibit the absorption of water from the colon.

After oral administration the laxative effect of the sulfuric acid ester starts considerably earlier than that of the free diphenol. The reasons for this difference are discussed.

Key words

Colon Water Absorption Sulfuric Acid Ester of 4,4′-Dihydroxydiphenyl-(Pyridyl-2)-Methane 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • W. Forth
    • 1
  • G. Nell
    • 1
  • W. Rummel
    • 1
  • H. Andres
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie der Universität des SaarlandesHomburg (Saar)

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