Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase

  • David F. Fitzpatrick
  • Andor Szentivanyi
Article

Summary

Enhancement of calcium uptake into rabbit aortic microsomes was seen at a cyclic AMP concentration of 10−6M in the presence of cyclic AMP-dependent protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37). Protein kinase alone also increased calcium uptake, but cyclic AMP alone was without effect. The results suggest that stimulation of calcium sequestration may be the mechanism of cyclic AMP involvement in vascular smooth muscle relaxation.

Key words

Calcium Cyclic AMP Vascular smooth muscle Microsomal vesicles 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • David F. Fitzpatrick
    • 1
  • Andor Szentivanyi
    • 1
  1. 1.Department of Pharmacology, College of MedicineUniversity of South Florida Medical CenterTampaUSA

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