Receptor desensitization by lobeline and nicotine
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In frog sartorius muscles, lobeline had no effect on resting membrane potentials but prevented depolarization of the fibers by nicotine. The blockade caused by lobeline was not antagonized by elevated concentrations of nicotine. Procedures that prevented depolarization of the fibers by nicotine had no effect on the anti-nicotinic effects of nicotine. It was concluded that receptor desensitization in skeletal muscle does not require depolarization of the fibers.
Key wordsLobeline Nicotine Receptor Desensitization
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