Receptor desensitization by lobeline and nicotine

  • Robert L. Volle
  • Linda Reynolds


In frog sartorius muscles, lobeline had no effect on resting membrane potentials but prevented depolarization of the fibers by nicotine. The blockade caused by lobeline was not antagonized by elevated concentrations of nicotine. Procedures that prevented depolarization of the fibers by nicotine had no effect on the anti-nicotinic effects of nicotine. It was concluded that receptor desensitization in skeletal muscle does not require depolarization of the fibers.

Key words

Lobeline Nicotine Receptor Desensitization 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ariens, E. J., Simonis, A. M.: Drug receptor interaction. Acta physiol. pharmacol. neerl. 11, 151–172 (1962).Google Scholar
  2. Hancock, J. C., Henderson, E. G.: Antinicotinic action of nicotine and lobeline on frog sartorius muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 272, 307–324 (1972).Google Scholar
  3. Katz, B., Thesleff, S.: A study of the “desensitization” produced by acetylcholine at the motor end-plate. J. Physiol. (Lond.) 138, 63–80 (1957).Google Scholar
  4. Nastuk, W. L., Gissen, A. J.: Actions of acetylcholine and other quaternary ammonium compounds at the muscle postjunctional membrane. In: Muscle, pp. 389–402. London: Pergamon Press 1965.Google Scholar
  5. Rang, H. P., Ritter, J. M.: A new kind of drug antagonism: Evidence that agonists cause a molecular change in acetylcholine receptors. Molec. Pharmacol. 5, 394–411 (1969).Google Scholar
  6. Steinberg, M. I., Volle, R. L.: A comparison of lobeline and nicotine at the frog neuromuscular junction. Naunyn-Schmiedeberg's Arch. Pharmacol. 272, 16–31 (1972).Google Scholar
  7. Thesleff, S.: The mode of neuromuscular block caused by acetylcholine, nicotine, decamethonium and succinylcholine. Acta physiol. scand. 34, 218–231 (1955).Google Scholar
  8. Wang, C. M., Narahashi, T.: Mechanism of dual action of nicotine on end-plate membranes. J. Pharmacol. exp. Ther. 182, 427–441 (1972).Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Robert L. Volle
    • 1
  • Linda Reynolds
    • 1
  1. 1.Department of PharmacologyUniversity of Connecticut Health CenterFarmingtonUSA

Personalised recommendations