Effects of quinidine, procaine amide, and N-propyl-ajmaline on skeletal muscle

  • J. Senges
  • R. Rüdel
  • E. Kuhn
Article

Summary

Membrane and action potentials of rat diaphragm fibres were measured in vitro as affected by quinidine, procaine amide, and N-propyl-ajmaline in concentrations of 10−5 to 10−4 g/ml.

All three drugs had immediate effects on the action potential; the effects progressed the faster, the higher the concentration: the de- and repolarization were slowed, the duration increased, the overshoot decreased. Later (e.g., 1 h after application of 10−5 g/ml quinidine) the resting potential started to decrease and the fibres became inexcitable.

Electrical threshold was increased and the refractory period was prolonged by all three drugs, most effectively by N-propyl-ajmaline, least by procaine amide. All drugs abolished myotonic symptoms produced by reduction of extracellular chloride.

Quinidine and N-propyl-ajmaline (10−5 to 10−4 g/ml) produced a transitory increase of contraction force, on prolonged drug action the muscle went into contracture. Procaine amide always had a negative inotropic effect. All drugs increased contraction time.

Key words

Antiarrhythmic Drugs Myotonia Skeletal Muscle 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • J. Senges
    • 1
    • 2
  • R. Rüdel
    • 1
    • 2
  • E. Kuhn
    • 1
    • 2
  1. 1.Medizinische Poliklinik der Universität HeidelbergHeibelbergGermany
  2. 2.Physiologisches Institut der Technischen Universität MünchenMunichGermany

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