Biochemical Genetics

, Volume 18, Issue 9–10, pp 843–849 | Cite as

Distribution of CAIII in fetal and adult human tissue

  • Stephen Jeffery
  • Yvonne Edwards
  • Nicholas Carter
Article

Abstract

Carbonic anhydrase III (CAIII), an enzyme recently shown by conventional electrophoresis to be muscle specific, has been quantitated by “rocket” immunoelectrophoresis. This more sensitive technique has shown that the enzyme is virtually specific to skeletal muscle, where it occurs at a level of 5mg/g, with trace levels in smooth muscle, cardiac muscle, and lung. In man there does not appear to by any correlation between CAIII levels and the proportion of red and white muscle fibers. The fetal development of CAIII has also been examined using immunoelectrophoresis, and the enzyme can be detected at 11 weeks' gestation. The CAIII level rises gradually up to 25 weeks, and there is then a more dramatic increase to reach approximately half adult level at birth.

Key words

carbonic anhydrase muscle fetal development 

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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Stephen Jeffery
    • 1
  • Yvonne Edwards
    • 2
  • Nicholas Carter
    • 1
  1. 1.Department of Child HealthSt George's Hospital Medical SchoolLondonEngland
  2. 2.MRC Human Biochemical Genetics Unit, The Galton LaboratoryUniversity College LondonLondonEngland

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