Summary
The inhibitory effect of roquefortine, a secondary metabolite of Penicillium roqueforti, on bacterial protein, RNA and DNA synthesis was studied. Similar results were obtained in colorimetric measurements and in studying the incorporation of radioactive precursors. They show that RNA synthesis was most significantly affected by roquefortine. Inhibition of protein and DNA synthesis was less pronounced and might be a result of primary inhibition of RNA synthesis.
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Abbreviations
- RNA:
-
ribonucleic acid
- DNA:
-
desoxyribonucleic acid
- DMSO:
-
dimethylsulfoxide
- Cpm:
-
counts per min
- ATCC:
-
American Type Culture Collection
References
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Kopp, B., Rehm, H.J. Studies on the inhibition of bacterial macromolecule synthesis by roquefortine, a mycotoxin from Penicillium roqueforti . European J. Appl. Microbiol. Biotechnol. 13, 232–235 (1981). https://doi.org/10.1007/BF00500104
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DOI: https://doi.org/10.1007/BF00500104