Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 275, Issue 3, pp 339–342 | Cite as

Vascular effects of the dinitrate and mononitrate esters of isosorbide, isomannide and isoidide

  • M. G. Bogaert
  • M. T. Rosseel
Short Communication


The vasodilator potency of different isomeric organic nitrates was tested on the perfused hindleg of the dog. The dinitrates and mononitrates of isosorbide, isomannide and isoidide have an increased potency if the nitrate groups are in the exo-position; for the mononitrates, potency is increased if the hydroxy group assumes the same position as the nitrate group.

Key words

Nitrates Vasodilator Potency Isomeric Organic Nitrates 


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  1. Anteunis, M., Verhegge, G., Rosseel, M. T.: Configurational and conformational insights on exo- and endo-1,4:3,6-dianhydroglucitol mononitrate. Org. Magn. Resonance. 3, 693–701 (1971).Google Scholar
  2. Beck, L.: Active reflex dilatation, in the innervated perfused hind leg of the dog. Amer. J. Physiol. 201, 123–128 (1961).Google Scholar
  3. Blum, S. W., Quinn, J. B., Howe, B. B., Hefner, M. A., Winbury, M. M.: Pharmacologic and biochemical evaluation of organic nitrates: attempted correlation of activities. J. Pharmacol. exp. Ther. 176, 684–691 (1971).Google Scholar
  4. Goldberg, L.: Pharmacological properties of sorbide dinitrate. Acta physiol. scand. 15, 173–187 (1948).Google Scholar
  5. Halliday, J. E., Clark, S. C.: Pharmacological properties of isoidide dinitrate. J. Pharm. Pharmacol. 17, 309–315 (1965).Google Scholar
  6. Needleman, P., Blehm, D. J., Rotskoff, K. S.: Relationship between glutathione-dependent denitration and the vasodilator effectiveness of organic nitrates. J. Pharmacol. exp. Ther. 165, 286–288 (1969).Google Scholar
  7. Rosseel, M. T., Bogaert, M. G.: Isosorbide, isomannide and isoidide dinitrate: Urinary excretion in the rat. Biochem. Pharmacol. (in press) (1972).Google Scholar
  8. Wendt, R. L.: Systemic and coronary vascular effects of the 2- and the 5-mononitrate esters of isosorbide. J. Pharmacol. exp. Ther. 180, 732–742 (1972).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • M. G. Bogaert
    • 1
  • M. T. Rosseel
    • 1
  1. 1.J. F. and C. Heymans Institute of PharmacologyUniversity of GhentBelgium

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