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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 275, Issue 3, pp 339–342 | Cite as

Vascular effects of the dinitrate and mononitrate esters of isosorbide, isomannide and isoidide

  • M. G. Bogaert
  • M. T. Rosseel
Short Communication

Summary

The vasodilator potency of different isomeric organic nitrates was tested on the perfused hindleg of the dog. The dinitrates and mononitrates of isosorbide, isomannide and isoidide have an increased potency if the nitrate groups are in the exo-position; for the mononitrates, potency is increased if the hydroxy group assumes the same position as the nitrate group.

Key words

Nitrates Vasodilator Potency Isomeric Organic Nitrates 

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References

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • M. G. Bogaert
    • 1
  • M. T. Rosseel
    • 1
  1. 1.J. F. and C. Heymans Institute of PharmacologyUniversity of GhentBelgium

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