Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 275, Issue 3, pp 233–241 | Cite as

The effect of pilocarpine and oxotremorine on hormone-activated copulatory behavior in the ovariectomized hamster

  • Leif H. Lindström


The effect of cholinergic compounds on hormone activated copulatory behavior in the ovariectomized hamster was studied. Pilocarpine and oxotremorine decreased the lordosis response elicited by estrogen plus progesterone at a time which coincided with the time for maximal muscarinic symptoms. This effect was prevented by atropine but not by methyl-atropine pretreatment. Pilocarpine could also activate the copulatory behavior after estrogen treatment only. This effect was obtained after the muscarinic symptoms had disappeared. These data are in general agreement with those previously found in the female rat. However, in contrast to the rat, the inhibitory effect of pilocarpine and oxotremorine on lordosis response in the hamster was not prevented by pretreatment with reserpine or p-chlorophenylalanine and the lordosis activating effect of pilocarpine was counteracted by methyl-atropine pretreatment. In both species, reserpine followed by pilocarpine treatment induced a clearcut tremor, which was not seen after either drug alone. It is suggested that the mechanism of action by which cholinergic drugs exert an inhibitory effect on hormone activated copulatory behavior is partly different in the rat and the hamster.

Key words

Cholinergic Drugs Reserpine Copulatory Behavior Female Hamster 


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  1. Calne, B.: Parkinsonism: physiology, pharmacology and treatment. 1 ed. London: Edw. Arnold Ltd. 1970Google Scholar
  2. Koe, K., Weissman, A.: p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. exp. Ther. 154, 499–516 (1966).Google Scholar
  3. Lindström, L. H.: The effect of pilocarpine and oxotremorine on oestrous behaviour in female rats after treatment with monoamine depletors or monoamine synthesis inhibitors. Europ. J. Pharmacol. 15, 60–65 (1971).Google Scholar
  4. Lindström, L. H.: Further studies on cholinergic mechanisms and hormone activated copulatory behaviour in the female rat. J. Endocrinol. (in press) (1972).Google Scholar
  5. Lindströ, L. H., Meyerson, B. J.: The effect of pilocarpine, oxotremorine and arecolin in combination with methyl-atropine or atropine on hormone activated oestrous behaviour in ovariectomized rats. Psychopharmacologia (Berl.) 11, 405–413 (1967).Google Scholar
  6. Meyerson, B. J.: Central nervous monoamines and hormone induced estrus behaviour in the spayed rat. Acta physiol. scand 63, suppl. 241 (1964a).Google Scholar
  7. Meyerson, B. J.: The effect of neuropharmacological agents on hormone activated estrus behavior in ovariectomized rats. Arch. int. Pharmacodyn. 150, 4–33 (1964b).Google Scholar
  8. Meyerson, B. J.: Estrus behavior in spayed rats after estrogen or progesterone treatment in combination with reserpine or tetrabenazine. Psychopharmacologia (Berl.) 6, 210–218 (1964c).Google Scholar
  9. Meyerson, B. J.: Monoamines and hormone activated oestrous behavior in the ovariectomized hamster. Psychopharmacologia (Berl.) 18, 50–57 (1970a).Google Scholar
  10. Meyerson, B. J., Lewander, T.: Serotonin synthesis inhibition and estrous behavior in female rats. Life Sci. 9, 661–671 (1970b).Google Scholar
  11. Nagatsu, T., Levitt, M., Udenfriend, S.: Tyrosine hydroxylase: the initial step in norepinephrine biosynthesis. J. biol. Chem. 239, No. 9 (1964).Google Scholar
  12. Siegel, S.: Nonparametric statistics for the behavioural sciences. London: McGraw Hill 1956.Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Leif H. Lindström
    • 1
  1. 1.Department of PharmacologyUniversity of UppsalaUppsalaSweden

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